Relationship of alveolar permeability and lung inflammation in patients with active diffuse infiltrative lung disease detected by 99Tcm-DTPA radioaerosol inhalation lung scintigraphy and quantitative 67Ga lung scans.

Abstract

The alveolar permeability (AP) in 21 patients with active diffuse infiltrative lung disease (ILD) was measured by 99Tcm-diethylenetriaminapentaacetate (DTPA) radioaerosol inhalation lung scintigraphy. The degree of AP damage in ILD was presented as the slope (% min-1) of the time-activity curve from the dynamic lung image. Meanwhile, the quantitative Ga lung scan (GA) was performed as a Ga uptake index (GUI) to evaluate the severity of lung inflammation in active ILD. The results show that no good correlation between the degree of AP damage and lung inflammation was found. When the patients were divided into two groups of (A) eight active ILD with normal chest X-ray (X-ray) and (B) 13 active ILD with abnormal X-ray, there was no significant difference between groups A and B for the DTPA and Ga results. In conclusion, the relationship between the degree of AP damage and lung inflammation in active ILD is not significant. This was not consistent with X-ray findings. There was, however, a significant difference between those with ILD and normal controls.