Relationship between Widal test Titer Levels with Lymphocyte and Platelet Count Fever Patients in Typhoid at Porsea Regional General Hospital, North Sumatra

Abstract

Abstract: Introduction: Typhoid fever is a a bacterial infection caused by Salmonella typhi. Salmonella typhi infection is bacteremic which enters the small intestine and then spreads to the bone marrow. Diagnosis of Samonella typhi using Widal test and routine blood tests. Widal test and routine blood tests to see the body's mechanism against lymphocytes and platelets which are produced in the bone marrow and function as the body's defense against infection. When these bacteria reach the bone marrow, it will inhibit the formation of lymphocytes and platelets. This is also due to the presence of endotoxin from bacteria so that in cases of typhoid , lymphocytosis and thrombocytopenia occur. Objective: To determine the relationship between Widal titer and the number of lymphocytes and platelets in patients with typhoid fever. Research methods: Analytical Observation. The number of samples used as many as 24 samples using primary data. The data collected is in the form of Widal titer with the number of lymphocytes and platelets. Then processed using the Pearson Correlation. Results: The mean of lymphocytes on the O antigen with a titer of 1/160 was 24.84%, a titer of 1/320 was 43.95%, the mean of platelets with a titer of 1/160 was 312,000 gL and a titer of 1/320 was 230,750 gL. While on H antigen the mean number of lymphocytes with a titer of 1/160 is 35.48% and a titer of 1/320 is 39.86%. The mean platelet count with a titer of 1/160 is 196,670 gL and a titer of 1/320 is 158,000 gL. Statistical test results p>0.05. Conclusion: There is no relationship between Widal titer and the number of lymphocytes and platelets in typhoid at the Gunungsari Health Center, West Lombok. Keywords : Typhoid fever, Widal, Lymphocytes, Platelets