Relationship between Vision-Related Quality of Life and Central 10\xb0 of the Binocular Integrated Visual Field in Advanced Glaucoma

Yoshio Yamazaki,Shun Matsumoto,Satoshi Okinami,Toshihiro Inoue,Makoto Araie,Kenji Sugisaki,Keiji Yoshikawa,Koichi Mishima,Shinichiro Ishikawa,Hidetaka Maeda,Kenji Mizuki,Akiyasu Kanamori,Kenichi Uchida,Yuko Yamada,Masaru Inatani,Hiroshi Murata,Akira Negi,Hidenobu Tanihara

doi:10.1038/s41598-019-50677-0

Abstract

To investigate the relationships between sensitivity loss in various subfields of the central 10° of the binocular integrated visual field (IVF) and vision-related quality of life (VRQoL) in 172 patients with advanced glaucoma. Using the Random Forest algorithm, which controls for inter-correlations among various subfields of the IVF, we analysed the relationships among the Rasch analysis-derived person ability index (RADPAI), age, best-corrected visual acuity (BCVA), mean total deviations (mTDs) of eight quadrant subfields in the IVF measured with the Humphrey Field Analyzer (HFA) 10-2 program (10-2 IVF), and mTDs of the upper/lower hemifields in the IVF measured with the HFA 24-2 program (24-2 IVF). Significant contributors to RADPAIs were as follows: the inner and outer lower-right quadrants of the 10-2 IVF contributed to the dining and total tasks; the lower-left quadrant of the 10-2 IVF contributed to the walking, going out and total tasks; the lower hemifield of the 24-2 IVF contributed to the walking, going out, dining, miscellaneous and total tasks; and BCVA contributed more to the letter, sentence, dressing and miscellaneous tasks than to others. The impact of damage in different 10-2 IVF subfields differed significantly across daily tasks in patients with advanced glaucoma.

Highlights

To investigate the relationships between sensitivity loss in various subfields of the central 10° of the binocular integrated visual field (IVF) and vision-related quality of life (VRQoL) in 172 patients with advanced glaucoma
Crabb et al.[7] proposed an integrated binocular VF score that was based on simultaneous binocular VF results, using the maximum sensitivity from each of corresponding points; they found that integrated VF (IVF) scores were more strongly associated with self-reported visual disabilities than were Esterman disability scores
We evaluated VRQoL in 172 patients (55 males, 117 females) with advanced glaucoma; 138 patients had primary open-angle glaucoma, 8 had primary angle-closure glaucoma, 6 had pseudoexfoliation glaucoma, 4 had developmental glaucoma and 16 had secondary glaucoma

Summary

Introduction

To investigate the relationships between sensitivity loss in various subfields of the central 10° of the binocular integrated visual field (IVF) and vision-related quality of life (VRQoL) in 172 patients with advanced glaucoma. The questionnaire was used to examine the relationship between VRQoL and mean retinal sensitivity for a cluster in the binocular IVF, using a Humphrey Field Analyzer (HFA; Carl Zeiss, Dublin, CA, USA) with the Swedish Interactive Threshold Algorithm standard (SITA-S) central [] program (HFA 30-2) that followed the best location model. They evaluated the impact of damage in different subfields on the performance of different daily tasks and demonstrated that sensitivity in the lower central 5° of the VF was most important for the VRQoL of glaucoma patients[10]. VF defects close to the point of fixation are more likely to threaten central vision than are defects farther into the periphery[12]; notably, the central VF, which is very important for visual function, is usually preserved until the end stages of glaucoma[6,12,13,14,15,16]

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