Abstract
Relationship Between Uterine Development, mRNA and Protein Expression of FSH and LH Receptors in New Zealand White Rabbits
Highlights
The female rabbit possesses a bicornuate duplex uterus
The mutations of follicle-stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHR) lead to female reproductive dysfunction (Costagliola et al, 2005)
This study aimed to investigate the rabbit uterine histological changes and their relationship with expression patterns of LHR and FSHR at mRNA and protein levels from birth to maturity and during pregnancy, which would help to broaden our knowledge of the expression of both gonadotropin receptors in extragonadal tissues that may contribute to the improvement of rabbit reproduction
Summary
The female rabbit possesses a bicornuate duplex uterus. This type of uterus has two separate uterine horns ended by two united services and the two cervices open into a single vagina (Abd-Elkareem, 2017). Most female reproductive organs have completed organogenetic differentiation and development at birth, the uterus is not completely differentiated at birth (Spencer et al, 2005). Even though the uterus is critical for female fertility, the cell, hormonal and molecular pathways that regulate uterine development are less understood (Hu et al, 2004). The interactions of FSH and LH with their receptors is a critical step in the regulation of mammalian gonadal function and female reproductive development (Dias et al, 2002).
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