Relationship between using proton pump inhibitors to prevent stress ulceration and the hospital-acquired pneumonia in severe craniocerebral injury patients

Abstract

Objective To investigate whether using proton pump inhibitors (PPI) to prevent stress ulceration increase the incidence of hospital acquired pneumonia (HAP) in severe craniocerebral injury patients.Methods 120 case with severe craniocerebral injury for more than 7 days in our hospital in recent one year were analyzed and compared the incidence of HAP between using PPI and not.Results There were 83 cases using PPI in 120 cases of severe craniocerebral injury and 29 occurring HAP.The infection rate was 34.94％,especially with continued use ≥ 7days it was 47.05％.There were 34 cases without using PPI,4 found occurring HAP.The infection rate was 10.81％.Conclusions The incidence rate of HAP in patients with severe craniocerebral injury using PPI is significantly higher than that of those without using PPI.And incidence rate of HAP in the long-term use of PPI is obviously higher than the short-term one.The clinical doctors should choose drug and control drug using time according to the specific situation of patients,to reduce the incidence of HAP,and relieve pain of patients and reduce waste of resources. Key words: Proton pump inhibitors; Severe craniocerebral injury; Hospital-acquired pneumonia