Abstract
Considerable controversy exists with regard to the physiological role of the renal kallikrein-kinin system in regulating renal sodium handling. It has been both suggested and denied that a positive relationship exists between urinary sodium excretion and kallikrein activity. This discrepancy may relate in part to the experimental manipulations used to achieve extracellular fluid volume expansion, since the infusion of exogenous solutions is frequently accompanied by alterations in plasma composition and urine flow which may affect the kallikrein- kinin system independently of volume alterations. The successful characterization of the water immersion model (NI) and the demonstration that it induces acute central hypervolemia without concomitant alterations in plasma composition commended its utilization in the present study. The NI model was used to assess in a kinetic fashion the relationship between urinary kallikrein excretion and renal sodium handling. Normal subjects were studied after 11 h of dehydra...
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