Relationship between Uric Acid, Creatinine, Urea and Triglyceride Production in Gout

Abstract

Background: Gout is a disorder that manifests as a spectrum of clinical and pathologic features built on a foundation of an excess body burden of uric acid, Hyperuricemia and gout are two of the most common metabolic diseases, there has been an increase in the prevalence and has attracted attention as an adult lifestyle-associated disease.
 Objective: The present study was carried to determine the prevalence of goat and uric acid, creatinine, urea, and triglyceride production in patients with hyperuricemia.
 Materials and Methods: Cross sectional study was done to examine associative between (November 2017 to February 2018). Totally 66 patient attended from ( Hawler Private Hospital, Rezgari Governmental Hospital, Ankawa Private Laboratory) in Erbil and may have hyperuricemia can be developed to gout disease from both males (32) and females (34) .the age 18 up to 70 who included in this study. Biochemical tests were performed for all patients (uric acid test, urea test, creatinine test, triglyceride test). These samples were analyzed by using blood serum rather than urine.
 Results: In male statistical analysis showed that significant correlation between high uric acid and age, the age group (41-60) years was significantly higher compared to other age groups (P < 0.05), and in female statistical analysis showed that significant correlation between high uric acid and age, the age group (61-80) years was significantly higher compared to other age groups (P < 0.05). In male statistical analysis showed that significant correlation between high creatinine and age , the age group (41-60) years was significantly higher compared to other age groups (P < 0.05), in female statistical analysis showed that significant correlation between high creatinine and age, the two age groups (41-60) & (61-80) years were significantly higher compared to other age group (P < 0.05). In male statistical analysis showed that significant correlation between high urea and age, the age group (41-60) years was significantly higher compared to other age groups (P < 0.05), in female statistical analysis showed that non-significant correlation between high urea and age groups (P > 0.05). In male statistical analysis showed that significant correlation between high TG and age , the age group (41-60) years was significantly higher compared to other age groups (P < 0.05), in female statistical analysis showed that non-significant correlation between high TG and age groups (P > 0.05).
 Conclusion: gout is a very common form of arthritis might be increasing hinderance of activity of daily living, lifestyle and environmental factors. Although not life-threatening, it has a significant impact on quality of life. The results provide support for possible linkage of influencing creatinine and triglyceride and uric acid and triglyceride with gout.