Relationship between Two AMI Risk Factors: Low Serum Lipoprotein Lipase Mass and Hypoadiponectinemia

Abstract

Recent clinical studies have reported that low lipoprotein lipase mass in preheparin serum (s-LpL) and hypoadiponectinemia are important risk factors for acute myocardial infarction (AMI). The aim of this study was to elucidate the relationship between low s-LpL and hypoadiponectinemia, both of which are risk factors for AMI. One hundred and thirty-seven male patients with AMI and fifty-three males with normal coronary arteries (NCA) were enrolled in the study. Coronary risk factors, including s-LpL and serum total adiponectin concentrations (t-adiponectin), were compared. Both s-LpL and t-adiponectin were significantly lower in patients with AMI than in subjects with NCA (s-LpL, NCA: 48.1±11.0 ng/mL, AMI: 38.9±11.1 ng/mL, p< 0.01; t-adiponectin, NCA: 7.7±2.9 µg/mL, AMI: 6.1±3.3 µg/mL, p< 0.01). In AMI patients, there was a significant positive correlation between s-LpL and t-adiponectin (r=0.46, p< 0.01). Furthermore, multivariate analysis indicated that both s-LpL and t-adiponectin were independent variables for AMI (s-LpL: p< 0.05, t-adiponectin: p< 0.05). These results indicate that although low s-LpL and hypoadiponectinemia are associated with each other, they are independent risk factors for AMI.