Abstract
Objective To investigate the relationship between C1q/tumor necrosis factor(TNF)-related protein 9(CTRP9)and coronary heart disease. Methods A total of 232 patients diagnosed with coronary heart disease(CHD)by coronary angiography at our hospital were selected as the CHD group, and 90 cases with normal coronary angiography served as the control group. The double antibody sandwich enzyme-linked immunosorbent assay(ELISA)was used to determine serum CTRP9 levels. Results Serum CTRP9 levels were lower in the CHD patients than in the controls〔(116.9±19.5)ng/ml vs.(142.3±17.9)ng/ml, t=-5.404, P=0.000〕. Serum CTRP9 levels were negatively correlated with body mass index, fasting plasma insulin, fasting blood glucose, insulin resistance index(IRI), triglyceride and TNF-α(r=-0.230, -0.225, -0.267, -0.235, -0.230 and -0.222, P=0.017, 0.011, 0.002, 0.010, 0.011 and 0.022). Multiple logistic regression analysis revealed that uric acid, IRI, CTRP9, and TNF-α were independent influencing factors for CHD, of which CTRP9 was a protective factor for CHD occurrence(OR=0.907, 95%Cl: 0.854~0.963, P=0.001). Conclusions Decreased serum levels of CTRP9 are associated with coronary heart disease, indicating that CTRP9 may play a protective role in coronary heart disease occurrence. Key words: Coronary disease; Adipokines; Tumor necrosis factors
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