Abstract
Since the high level of meiotic recombination at the ARG4 locus of the budding yeast Saccharomyces cerevisiae was found to be controlled by a cis-acting initiator located within its 5′ noncoding region (1), the question of the relationship between transcription and meiotic recombination control was raised. Are promoters and sites at which meiotic recombination initiates functionally related? Transcription by RNA polymerase I and II appears to stimulate mitotic recombination in S. cerevisiae (2, 3), but how is meiotic recombination affected by local gene expression? The paper by Kon et al. (4), in conjunction with other recent contributions concerning the M26 hot spot of meiotic recombination in the fission yeast Schizosaccharomyces pombe, provides compelling new insights and prompts additional questions. This commentary/mini-review will focus on the control of the initiation of meiotic recombination in these yeasts.
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