Abstract
Background and Objectives: This study aimed to observe the relationship between trace element concentrations in lung tissue from lung non-small cell lung carcinoma (NSCLC) patients and prognosis. Materials and Methods: The concentrations of various trace elements in the lung tissues were measured by a particle-induced X-ray emission (PIXE) system, and the results were analyzed for statistical significance. Eight essential trace elements, Cr, Mn, Fe, Co, Cu, Zn, Se, and Mo, were analyzed. We investigated the relationship between trace element concentrations and disease-free survival (DFS) and overall survival (OS) in NSCLC patients. Results: A total of 129 NSCLC patients and 20 control patients were included in this study. As for DFS, Co was the only element that showed a significant difference, and the high Co group had better DFS (HR: 0.352, 95% CI = 0.128–0.97). No significant difference was observed for Cr, Mn, Fe, Se, or Mo, but DFS tended to be better in the high trace element group. No significant difference was observed for Cu and Zn, but DFS tended to be good in the low trace element group. As for OS, Cr was the only element that showed a significant difference, and the high Cr element group had better OS (HR: 0.477, 95% CI = 0.128–0.97). Conclusions: This study suggests that the prognosis is good in lung cancer cases with high intratumoral concentrations of Co and Cr. The dynamics of trace elements in body and in tumor tissue have not been well established, and we consider that more research is necessary in the future.
Highlights
Lung cancer is one of the most common cancers
We evaluated the relationship between essential trace elements and disease-free survival (DFS) and overall survival (OS) in tumor tissues of non-small cell lung carcinoma (NSCLC) patients
Of the 1157 patients who underwent surgical resection of lung tissue at our hospital, 150 whose trace elements could be analyzed participated in the study
Summary
Lung cancer is one of the most common cancers. molecular targeting drugs and immune checkpoint inhibitors have been developed recently, mortality of lung cancer remains high [1]. We analyzed the following trace elements by particle-induced X-ray emission (PIXE): Fe, Co, Ni, Cu, Zn, Ga, Ge, As, Se, Br, Rb, Sr, Y, Zr, Nb, Mo, Pd, Ag, Cd, In, Sn, Sb, Te, I, Cs, Ba, Ce, W, Pt, Au, Hg, and Pb. Pd, Ag, Cd, In, Sn, Sb, Te, I, Cs, Ba, Ce, W, Pt, Au, Hg, and Pb were not detected in any of the 129 non-small cell lung carcinoma (NSCLC) patients. This study aimed to observe the relationship between trace element concentrations in lung tissue from lung non-small cell lung carcinoma (NSCLC) patients and prognosis. Conclusions: This study suggests that the prognosis is good in lung cancer cases with high intratumoral concentrations of Co and Cr. The dynamics of trace elements in body and in tumor tissue have not been well established, and we consider that more research is necessary in the future
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
