Relationship between thrombocytosis and effect of chemotherapy, prognosis in patients with advanced non-small cell lung cancer

Abstract

Objective To study the prevalence of thrombocytosis in patients with non-small-cell lung cancer (NSCLC) and its correlation with clinicopathological features. Methods 156 patients with advanced NSCLC were retrospectively analyzed. The platelets degree between the groups with different sex, age, smoking, histological type of advanced NSCLC was compared and analyzed statistically. The relationship between the platelet count and chemotherapy effects was analyzed. Single analysis and Cox regression analysis were used for TTP and OS. Results Compared with the healthy persons, Plt significantly elevated in group with advanced NSCLC (36.5 % , 57/156 vs 5.0 % , 5/100) (P<0.01), and thrombocytosis group responded poorly to chemotherapy (22.8 %, 13/57 vs 39.4 %, 39/99) (P<0.05). The TTP (3.0 months vs 5.2 months) and OS (11.2 months vs 14.2 months) of Plt elevated group were significantly shorter than those of normal group. Conclusion Thrombocytosis is closely related to progress and metastasis of advanced NSCLC. Platelet count can be used as an assistant index in the prognosis judgment of patients with advanced NSCLC. Key words: Carcinoma, non-small-cell lung; Platelet count; Thrombocytosis; Prognosis