Relationship between the use of polymyxin B-immobilized fiber for hemofiltration and some laboratory parameters (endocannabinoids, high mobility group box-1 protein and oxidative stress) in severe pneumonia patients

K Mashiko,Y Sakamoto,Y Hara,T Obata,Y Yamamoto,H Matsumoto,N Kutsukata

doi:10.1186/cc6677

Abstract

Septic shock remains a major cause of multiple organ failure, with a high mortality rate, and severe pneumonia is one of the major causes of septic shock. The existence of a relationship between lung injury and the serum level of F2-isoprostane, as a known oxidative stress marker, was recently reported. The technique of direct hemoperfusion (DHP) with a polymyxin B-immobilized fiber column (PMX; Toray Industries Inc., Tokyo Japan) was developed in Japan in 1994, and it has been used for the treatment of endotoxemia in septic shock. Reduction of the serum levels of several endotoxins following PMX has been recognized.

Highlights

The aim of this study was to elucidate the impact of ICU-acquired infection on ICU and hospital mortality
The goal from this study is to evaluate weaning predictor indexes in patients during weaning from mechanical ventilation (MV)
This study aims to evaluate the effects of the threshold in such situations

Summary

Introduction

The aim of this study was to elucidate the impact of ICU-acquired infection on ICU and hospital mortality. Methods A total of 48 community patients (36 men, 11 women, age 50.17 ± 17.974 years, APACHE II score 13.51 ± 6.153) who were expected to stay in the ICU for >5 days were included in this study. Specific examples of feedback are as follows: ‘good update of management plan reinforces need for taking into account concurrent medication when resuscitating patients’, ‘nice simple messages with good starting points for trying to deal with these complicated patients’, ‘useful data on risk of recurrence as this is a question often asked by patients’ This feedback was encouraging as it showed how the primary care professionals planned to change their practice to improve patient outcomes as a result of the learning. The course was considered excellent by 63% of the participants and good by 36%

Methods

Results

Conclusion