Abstract
Background & aimsVarious studies have investigated the relationship between the polymorphism, rs2596542, in the promoter of the major histocompatibility complex class I-related gene A (MICA) gene with susceptibility to hepatitis B virus (HBV)/ hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC); however, the results are inconclusive. This meta-analysis was conducted to investigate the relationship between rs2596542 and HCV/HBV-induced HCC.MethodsThree electronic scientific publication databases (MEDLINE, Web of Science, and Embase) were screened using specific search terms and relevant literature identified using literature traceability methods. Selected publications were evaluated according to the inclusion and exclusion criteria, and 11 articles were included in the study. Effect size information (odds ratio [OR] and corresponding 95% confidence interval [CI]) were obtained following quality assessment and data extraction from the included publications, and a meta-analysis conducted.ResultsA total of 11 publications were included in the study, including 4582 patients with HCC and 21,095 non-HCC patients. TT genotype at rs2596542 was a risk factor for the development of HCC in patients with HCV/HBV infection (OR = 1.248, 95% CI: 1.040–1.499, P = 0.017), particularly those with HCV infection (OR = 1.326, 95% CI: 1.101–1.599, P = 0.003) and Asians (OR = 1.273, 95% CI: 1.002–1.618, P = 0.048), or when the control group was patients with chronic hepatitis C (CHC) (OR = 1.506, 95% CI: 1.172–1.936, P = 0.001).ConclusionThe findings of this meta-analysis suggest that the rs2596542 variant in the MICA promoter region may affect MICA and soluble MICA (sMICA) protein expression, thereby influencing physiological vulnerability to HCC cells and the development of HCC. These data provide a theoretical basis for the diagnosis and treatment of patients with HCC and viral hepatitis infection.
Highlights
Background & aimsVarious studies have investigated the relationship between the polymorphism, rs2596542, in the promoter of the major histocompatibility complex class I-related gene A (MICA) gene with susceptibility to hepatitis B virus (HBV)/ hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC); the results are inconclusive
The rs2596542 single nucleotide polymorphism (SNP) in the MICA promoter region may be associated with HCC induced by HCV [15], while the results of studies investigating the association of rs2569542 with susceptibility to HBV/HCV-induced HCC are variable [16,17,18], limiting their credibility
The remaining 78 articles were initially screened, based on the title and abstract, and 59 articles excluded for other reasons, including that: they were reviews, abstract compilations, or meeting reports (n = 30); they investigated other genes (n = 4); they only reported the relationship between soluble MICA (sMICA) expression and HCC (n = 9); or they investigated other diseases (n = 15)
Summary
Various studies have investigated the relationship between the polymorphism, rs2596542, in the promoter of the major histocompatibility complex class I-related gene A (MICA) gene with susceptibility to hepatitis B virus (HBV)/ hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC); the results are inconclusive. This meta-analysis was conducted to investigate the relationship between rs2596542 and HCV/HBV-induced HCC. Major histocompatibility complex class I-related gene A (MICA) is a tumor-associated gene containing numerous polymorphisms, which maps to the short arm of human chromosome 6 [9]. The aim of this study was to perform a meta-analysis of published reports concerning rs2596542 and HCC susceptibility, to provide more reliable evidence for basic research and clinical treatment
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