Relationship between the ratio of neutrophil/lymphocyte and risk stratification, prognosis in patients with non-ST-elevation acute coronary syndrome

Abstract

Objective: To investigate the value of neutrophil to lymphocyte ratio (NLR) in predicting risk stratification and prognosis in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods: A total of 227 NSTE-ACS patients after percutaneous coronary intervention (PCI) were collected from September 2012 to September 2014 in Beijing Anzhen Hospital.Groups: (1)According to NLR, the patients were divided into 3 groups: NLR<2.20 group; 2.2≤NLR<3.33 group; NLR≥3.33 group.(2)According to the global registry of acute coronary events (GRACE) score, the patients were divided into 3 groups: Low-risk group, Medium-risk group and High-risk group.(3)According to the occurrence of major adverse cardiac events (MACE), the patients were divided into 2 groups: MACE group and non MACE group.Receiver operator characteristic curve (ROC) was used to assess value of NLR for high risk NSTE-ACS patients.Then COX regression analysis was used to analyze correlation between NLR and MACE. Results: A total of 227 NSTE-ACS patients after PCI were collected and the ratio of MACE was 32.2% (73/227). The GRACE score and the incidence of MACE in NLR≥3.33 group were higher than those in 2.2≤NLR<3.33 group and NLR<2.20 group (all P<0.01). The level of NLR and the incidence of MACE in High-risk group were higher than those in Low-risk group and Medium-risk group (all P<0.05). The level of NLR and the GRACE score in MACE group were higher than those in non MACE group (all P<0.05). COX regression analysis indicated that NLR was independent risk factor for MACE occurrence in NSTE-ACS patients at 1 year after PCI (OR=1.214, 95%CI: 1.114-1.323, P=0.000). Conclusion: The level of NLR has significant correlation with High-risk NSTE-ACS patients, and NLR is an independent risk factor for poor prognosis in patients with NSTE-ACS.