Abstract
Background: Spina bifida is the second leading cause of motor disability in childhood. Therefore, it’s important to know if the therapeutic offer for spina bifida is fulfilling its demand. Objectives: To evaluate the relationship between the number of treatments and the incidence of spina bifida in Brazil, between 2016 and 2019. Design and Setting: Descriptive, retrospective study, with secondary data collected in the Hospital Information System of SUS (SIH / SUS) and the Information System of Live Births (SINASC), between 2016 and 2019, in Brazil. Methods: Variables used: frequency of spina bifida by live births and quantity of treatments. Results: In 2016, the frequency of spina bifida by live births was 746 and the number of procedures for treating the disease was 360, resulting in a 0.48 ratio between the treatment quantity and the affected live births. In 2017, the frequency was 711 and the procedure quantity was 337, with a 0.47 proportion. In 2018, the frequency was 726, the procedure quantity 294, with a 0.4 proportion. In 2019, the frequency decreased to 694, with 288 procedures, and a 0.41 proportion. In total, there were 2,877 live births with spina bifida and 1,300 hospital procedures, with a proportion of 0.45. Conclusions: The study shows a clear disparity between the frequency of spina bifida and the procedure quantity for this condition. In addition, the number of procedures was decreased, without a proportional declination in the disease incidence, indicating a need for greater public investment for such treatments.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation
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