Relationship between the Plasma Levels of Catecholamines and Return of Spontaneous Circulation in Patients with Out-of-Hospital Cardiac Arrest.

Yumi Ichikawa,Yuto Aramaki,Kiyohiro Oshima,Kazunori Fukushima,Yuta Isshiki,Yusuke Sawada,Jun Nakajima,Kee Chong Ng

doi:10.1155/2021/5324038

Yumi Ichikawa, Yuto Aramaki + Show 6 more

Open Access

https://doi.org/10.1155/2021/5324038

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Journal: Emergency medicine international	Publication Date: Jul 29, 2021
Citations: 4	License type: CC BY 4.0

Affiliation: Gunma University

Abstract

Purpose The dynamic state of epinephrine (Ep) in the plasma of patients with out-of-hospital cardiac arrest (OHCA) remains unclear. The purpose of this study was to evaluate the relationship between the plasma levels of catecholamines (such as epinephrine (Ep), norepinephrine (Nep), and dopamine) and vasopressin (antidiuretic hormone (ADH)) and the acquisition of return of spontaneous circulation (ROSC) in OHCA patients. Methods This was a prospective, observational clinical study. Patients with OHCA transferred to our hospital between July 2014 and July 2017 were enrolled. The levels of catecholamines and ADH in the plasma were measured using blood samples immediately obtained on arrival at our hospital and before the administration of Ep. Patients in whom Ep was already administered prior to obtaining blood samples were excluded. Patients were divided into two groups: with and without ROSC, that is, ROSC (+) and ROSC (−) groups, respectively. The plasma levels of these agents and the conditions of resuscitation were compared between the two groups. Results A total of 96 patients with OHCA were analyzed. The ROSC (+) and ROSC (−) groups included 34 and 62 patients, respectively. There were no significant differences observed between the two groups in age, cause of cardiopulmonary arrest, and prehospital resuscitation time. The plasma levels of Ep and Nep were significantly lower in the ROSC (+) group than in the ROSC (−) group. However, there were no significant differences in the plasma levels of dopamine and ADH between the two groups. Conclusion Increased levels of Ep in the plasma may not be associated with the acquisition of ROSC in patients with OHCA.

Highlights

Cardiac arrest remains a leading cause of mortality and morbidity in the United States of America and other countries worldwide [1]
We postulated that the higher plasma levels of catecholamines would be associated with the higher rate of return of spontaneous circulation (ROSC) acquisition. e purpose of this study was to evaluate whether the levels of catecholamines in the plasma on arrival at the hospital affect the acquisition of ROSC in patients with of-hospital cardiac arrest (OHCA)
cardiopulmonary resuscitation (CPR) performed. ere was a significant difference in the electrocardiogram waveform at the time of emergency service arriving at the scene, and the proportion of patients with ventricular fibrillation was larger in the ROSC (+) group than in the ROSC (−) group. erefore, the frequency of prehospital defibrillation was significantly higher in the ROSC (+) group

Summary

Research Article

E dynamic state of epinephrine (Ep) in the plasma of patients with out-of-hospital cardiac arrest (OHCA) remains unclear. E purpose of this study was to evaluate the relationship between the plasma levels of catecholamines (such as epinephrine (Ep), norepinephrine (Nep), and dopamine) and vasopressin (antidiuretic hormone (ADH)) and the acquisition of return of spontaneous circulation (ROSC) in OHCA patients. Ere were no significant differences observed between the two groups in age, cause of cardiopulmonary arrest, and prehospital resuscitation time. There were no significant differences in the plasma levels of dopamine and ADH between the two groups.

Introduction

Without enough data

Results

Pulmonary embolism