Relationship between the myocardial 99Tcm-MIBI uptake and the left ventricular synchronization in patients with dilated cardiomyopathy

Abstract

Objective To analyze the relationship between left ventricular myocardial 99Tcm-MIBI uptake and the left ventricular synchronization in patients with dilated cardiomyopathy (DCM). Methods Forty-three cases (30 males and 13 females, age (50.58±13.29) years) with DCM who underwent 12-lead electrocardiogram and rest gated MPI were included. Among them, 24 cases with QRS duration <120 ms was regarded as synchronous group, and 19 cases with QRS duration≥120 ms was regarded as dyssynchronous group. LVEF, PFR, ESV, EDV were recorded, and myocardial uptake of 99Tcm-MIBI, severity and extent in area of apex, anterior, lateral, inferior and septum wall of left ventricle were calculated respectively by quantitative perfusion SPECT (QPS)software. Independent sample t test and Mann-Whitney u test were used for data analysis with IBM SPSS 21.0. Results The values of LVEF were (26.44±5.59)% and(23.70±5.27)% in synchronous group and dyssynchronous group respectively (t=1.240, P>0.05). The other three cardiac function parameters had no significant differences between the two groups (t: 0.195, 0.113, 0.291, all P>0.05). There were no significant differences of myocardial 99Tcm-MIBI uptake between two groups in all segments of apex, anterior, lateral, inferior and septum wall (t: -0.712-1.059, all P>0.05). Deeper severities (0.6-3.3 s) and wider abnormal extents (0-65%) of myocardial 99Tcm-MIBI uptake were found only in the area of inferior wall in synchronous group, compared to those in dyssynchronous group (0.1-2.5 s, 0-36%; z=-2.266, -2.391, both P<0.05). Conclusions Myocardial injury (location, severity and extent)in patients with DCM could be detected by myocardial 99Tcm-MIBI imaging. The severity and extent of myocardial injury may have a significant impact on the left ventricular synchronization. Key words: Cardiomyopathy, congestive; Tomography, emission-computed, single-photon; MIBI