Relationship between the mutation of G239V point in SLC17A3 gene and primary gout

Abstract

Objective To explore the relationship between the mutation of G239V point in SLC 17A3 gene and primary gout.Methods The single nucleotide polymorphism (SNP) of gene in 530 sporadic patients with primary gout was detected with Taq man probe real-time fluorescence quantitative PCR.Results No mutation was detected the site of G239V in SLC17A3 gene in the 530 patients.Conclusions Attack of primary gout doesn' t correlate with the mutation of G239V point in SLC17A3 gene,indicating heterogeneity of primay gout. Key words: Gout ; SLC17A3 ; Single nucleotide polymorphism ; Taq man probe ; Real-time fluorescence quantitative PCR ;