Relationship between the level of triglyceride and the severity of hyperlipidemic acute pancreatitis

Abstract

Objective To investigate the relationship between the level of triglyceride(TG) and the severity of hyperlipidemic acute pancreatitis(HLAP). Methods From January 2013 to May 2017, 225 HLAP patients who were transferred to the Gastroenterology Department, Hepatobiliary Surgery Department and Critical Care Department were selected and their general data were retrospectively analyzed.The patients were divided into two groups according to the blood TG condition: 103 patients in the low TG group, 69 males and 34 females, aged(40.63±1.16) years old and ranging from 38 to 65 years old; 122 patients in the high TG group, 92 males and 30 females, aged(42.14±0.62) years old and ranging from 40 to 67 years old.The complications, biochemical indexes, complications and hospitalization indexes of the two groups were analyzed, and the clinical characteristics, severity and mortality of the two groups were compared. Results Blood glucose level[(13.82±0.78) mmol/L]in the high-TG group was higher than that in the low-TG group[(11.03±0.93) mmol/L], total cholesterol[(10.18±0.72) mmol/L]was higher than that in the low-TG group[(7.61±0.38) mmol/L], and blood urea nitrogen[(8.09±1.27) mmol/L]was higher than that in the TG group[(5.26±0.42) mmol/L], and the differences were statistically significant(P<0.05). The blood sodium content[(130.83±0.47) mmol/L]in the high-TG group was lower than that in the low-TG group[(137.43±0.42) mmol/L], (P<0.05). Patients with local complications under CT scan in the high-TG group were more than those in the low-TG group, and the severity of AP was higher than that in the low-TG group(P<0.05). ICU occupancy rate of patients in the low TG group[7.8%(8/103)]was lower than that in the high TG group[21.3%(26/122)], (P<0.05). Conclusion HLAP patients with high TG have serious condition, high ICU occupancy rate, high incidence of local complications under CT scan, and most of them have poor prognosis. Key words: Acute pancreatitis; Hyperlipidemias; Hyperlipidemic acute pancreatitis; Blood fat