Relationship between the effect of the first-line chemotherapy on advanced esophageal squamous cell carcinoma patients and LDL-C level

Abstract

Objective To analyze the relationship between the effect of the first-line chemotherapy on advanced esophageal squamous cell carcinoma patients and LDL-C level. Methods Sixty-four patients confirmed advanced esophageal squamous cell carcinoma from January 2012 to December 2015 were analyzed. The first-line chemotherapy were fluorouracil plus cisplatin. CLC-C level was detected before treatment begins. ORR and PFS were analyzed using T test and chi-square test and Kaplan-Meier method. Results There was 28 cases with the level of CLC-C higher than the upper limit, normal in 36 cases. The ORR and PFS were 17.9% and 7.1 months in high CLC-C level team; with the ORR and PFS were 38.8% and 9.0 months in normal team. ORR between the two groups had no significant difference (P>0.05), PFS was significant (P<0.05). Conclusions Higher LDL-C has close correlation with poor ORR and PFS in advanced esophageal squamous cell carcinomas patients. Key words: Low density lipoprotein; Esophageal squamous cell carcinoma; Advanced; Objective response rate; Progression-free survival