Abstract
SummaryThe dependency on x-irradiation dose of urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA) in rats was studied. A significant positive correlation between the applied doses: 50, 100, 150, 200, 400, 600 and 800 r, and 5-HIAA excretion-rate, was found. By means of this biochemical test it is possible to discriminate between animals irradiated with ‘low’ (50, 100, 150 r), ‘medium’ (200, 400 r) and ‘high’ (600, 800 r) doses. The maximal increase of 5-HIAA output after irradiation appears during the first 24 hours; excretion returns to normal values on the third day after irradiation. The females show a more pronounced response to radiation than the males. The dose of 200 r seems to be the lowest that significantly increases the output of 5-HIAA. The rats pre-treated with sub-lethal doses (50–200 r) respond to the subsequent dose of 800 r with somewhat delayed reaction.Some other urinary substances showing a certain irradiation dose-dependency are compared with 5-HIAA; the latter appears to be a good indicator for the evaluation of absorbed radiation dose.
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