Abstract
BackgroundThe Asthma Control Test (ACT) has been used to assess asthma control in both clinical trials and clinical practice. However, the relationships between ACT score and other measures of asthma impact are not fully understood. Here, we evaluate how ACT scores relate to other clinical, patient-reported, or economic asthma outcomes.MethodsA targeted literature search of online databases and conference abstracts was performed. Data were extracted from articles reporting ACT score alongside one or more of: Asthma Control Questionnaire (ACQ) score; rescue medication use; exacerbations; lung function; health−/asthma-related quality of life (QoL); sleep quality; work and productivity; and healthcare resource use (HRU) and costs.ResultsA total of 1653 publications were identified, 74 of which were included in the final analysis. Of these, 69 studies found that improvement in ACT score was related to improvement in outcome(s), either as correlation or by association. The level of evidence for each relationship differed widely between outcomes: substantial evidence was identified for relationships between ACT score and ACQ score, lung function, and asthma-related QoL; moderate evidence was obtained for relationships between ACT score and rescue medication use, exacerbations, sleep quality, and work and productivity; limited evidence was identified for relationships between ACT score and general health-related QoL, HRU, and healthcare costs.ConclusionsFindings of this review suggest that the ACT is an appropriate measure for overall asthma impact and support its use in clinical trial settings.GlaxoSmithKline plc. study number HO-17-18170.
Highlights
The Asthma Control Test (ACT) has been used to assess asthma control in both clinical trials and clinical practice
The analysis found that in 68 publications an improvement in ACT score was correlated or associated with improvements in key outcomes of interest (Table 1)
Six publications found strong and consistent correlations between improvement in ACT score and improvement in Asthma Control Questionnaire (ACQ) score [8,9,10,11,12,13], with five of the publications assessing the statistical significance of the correlations
Summary
The Asthma Control Test (ACT) has been used to assess asthma control in both clinical trials and clinical practice. We evaluate how ACT scores relate to other clinical, patient-reported, or economic asthma outcomes. The Asthma Control Test (ACT) provides a numerical score to assess the control of asthma [3]. A need remains to assess the link between ACT score and asthma treatment benefits and outcomes, and its suitability as an endpoint in clinical trials. The aim of the current study was to assess the extent to which ACT score is correlated, or associated, with other important clinical, patient-reported, and economic asthma outcomes
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