Abstract
BackgroundThe aim of the study was to evaluate the relationship between the area of isopters obtained using semi-automated kinetic perimetry (SKP) and Vigabatrin dosage in epilepsy patients with pretreatment baseline examination during 2-years of the follow-up.Methods29 epilepsy patients were included into the study, but 15 individuals were excluded due to cognitive impairment, intracranial pathologies or eye diseases. Finally, 14 patients were examined with SKP before VGB treatment and after 6, 12, 18, and 24 months. Reaction time (RT)-corrected areas of three isopters (III4e, I4e and I2e) were measured for each of five examinations and compared intra-individually during 2-years period. Additionally, six epilepsy patients on other antiepileptic drugs were examined five times with SKP as a control.ResultsThere was a significant decrease of I2e, I4e and III4e isopters’ area during the follow-up of two years. Correlation was found between the I2e isopter’s area and both cumulative dose and mean daily dose of VGB. With increasing RT, there was decreasing of all isopters’ area in patients receiving VGB. In epilepsy patients who were not receiving VGB, there were no significance differences in isopters’ area during follow-up.ConclusionThere was attenuation of area of III4e, I4e and I2e isopters obtained with SKP during a period of 2 years. RT, the cumulative dose and the mean daily dose of VGB influenced isopters' area obtained with SKP.
Highlights
The aim of the study was to evaluate the relationship between the area of isopters obtained using semi-automated kinetic perimetry (SKP) and Vigabatrin dosage in epilepsy patients with pretreatment baseline examination during 2-years of the follow-up
Vigabatrin (VGB) (Sabril, Hoechst Marion Russel/Aventis Ltd) is a selective irreversible inhibitor of the gammaaminobutric acid -transaminase [1] used in the management of partial epilepsy if it cannot be controlled satisfactorily by conventional therapy
Perimetry seems to be the best method to screen and monitor the visual function in patients taking VGB, there is no consensus in the literature as to the optimum perimetric test and there is no good method to quantify the visual field (VF) loss
Summary
The aim of the study was to evaluate the relationship between the area of isopters obtained using semi-automated kinetic perimetry (SKP) and Vigabatrin dosage in epilepsy patients with pretreatment baseline examination during 2-years of the follow-up. Perimetry seems to be the best method to screen and monitor the visual function in patients taking VGB, there is no consensus in the literature as to the optimum perimetric test and there is no good method to quantify the VF loss. In clinical practice most of the patients treated with VGB are examined with static perimetry within 60° [6] or 30° [7] or 24° [8] of eccentricity. Monitoring of visual function to understand the occurrence and manage the potential consequences of peripheral VF defects is required for all patients who receive VGB [10]
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