Abstract
Membrane lipid peroxidation (LPO) induced by hydroxyl ( OH) and ascorbyl ( Asc) radicals and by peroxynitrite (ONOO −) was investigated in asolectin (ASO), egg phosphatidylcholine (PC) and PC/phosphatidic acid mixtures (PC:PA) liposomes and rat liver microsomes (MC). Enthalpy variation (Δ H) of PC:PA at different molar ratios were obtained by differential scanning calorimetry. It was also evaluated the LPO inhibition by quercetin, melatonin and Vitamin B 6. The oxidant effect power follows the order OH ≈ Asc > ONOO − on PC and MC; whilst on ASO liposomes, it follows Asc > OH ≈ ONOO −. Increasing amounts of PA in PC liposomes resulted in lower levels of LPO. The Δ H values indicate a more ordered membrane arrangement as a function of PA amount. The results were discussed in order to provide a complete view involving the influence of membranes, oxidants and antioxidants intrinsic behavior on the LPO dynamics.
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