Relationship between TG/HDL-C Ratio and TyG Index with Chronic Inflammation in People with Prediabetes: A Cross-Sectional Study

Abstract

Objective: Prediabetes is an insulin resistance (IR) condition. The triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio and triglyceride-glucose (TyG) index were associated with prediabetes and IR condition which are related to cardiovascular disease (CVD). High sensitive-CRP (hs-CRP) is a marker of inflammation that is closely related to CVD. The aim of this study is to determine the correlation between TG/HDL-C ratio and TyG index with hs-CRP as a marker of chronic inflammation in impaired fasting glucose (IFG). Material and methods: An observational study with a cross-sectional approach involved 92 people with prediabetes in Makassar City, Indonesia, in February 2022. Research subjects were participants from Makassar Lipid and Diabetes Study aged 18–70 years who met inclusion criteria. Triglyceride, HDL-C, fasting plasma glucose (FPG), and hs-CRP were examined. Level of hs-CRP > 3–10 mg/L is a high risk of CVD. Prediabetes is defined by fasting plasma glucose of 100–125 mg/dL. Statistical analysis was performed using Kruskal-Wallis and Chi-Square tests. Results: The mean TG/HDL-C ratio was 4.88, the mean TyG index was 4.92, and the mean hs-CRP level was 4.53 ± 2.91 mg/L. There was no statistically significant relationship between TG/HDL-C ratio and high hs-CRP levels in people with prediabetes (p = 0.45). There was no statistically significant relationship between the TyG index and high hs-CRP levels in people with prediabetes (p = 1.00). Conclusions: There is no statistically significant relationship between TG/HDL-C ratio or TyG index and hs-CRP in people with prediabetes defined by IFG.