Abstract
MR-guided high-intensity focused ultrasound (HIFU) for treatment of uterine fibroids and painful bone metastases uses the proton resonant frequency shift (PRF) for temperature monitoring in water-based tissues. However, PRF fails to detect temperature changes in tissues with high lipid content, such as fat and bone marrow. Previous studies have shown a change in T2 of subcutaneous fat, red and yellow bone marrow during treatments with focused ultrasound. The lack of calibration data for 3T acquisitions, however, makes it difficult to convert T2 values into maps of tissue temperature. In this study we investigated the dependence of T2 temperature on temperature in porcine adipose tissue and bovine yellow bone marrow at thermal equilibrium at 3T.
Highlights
Background/introduction MR-guided high-intensity focused ultrasound (HIFU) for treatment of uterine fibroids and painful bone metastases uses the proton resonant frequency shift (PRF) for temperature monitoring in water-based tissues
In this study we investigated the dependence of T2 temperature on temperature in porcine adipose tissue and bovine yellow bone marrow at thermal equilibrium at 3T
Two petri dishes were filled with porcine adipose tissue and bovine yellow bone marrow and placed in a custom-built thermally insulated water bath that was held at a constant temperature by circulating water between scans
Summary
Relationship between temperature and T2 in subcutaneous fat and bone marrow at 3T Background/introduction MR-guided high-intensity focused ultrasound (HIFU) for treatment of uterine fibroids and painful bone metastases uses the proton resonant frequency shift (PRF) for temperature monitoring in water-based tissues. PRF fails to detect temperature changes in tissues with high lipid content, such as fat and bone marrow.
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