Relationship between Single Nucleotide Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Gene and Fatty Acid Composition in Korean Native Cattle.

Jea-Young Lee,Seunguk Lee,Dong-Yep Oh,Hyun-Ji Kim,Yong-Soo Park,J.-J Kim,Seyoung Mun,Jae-Jung Ha,Kyudong Han,Jun-Koo Yi

doi:10.5713/ajas.15.0502

Abstract

The peroxisome proliferator-activated receptor gamma (PPARγ) gene plays an important role in the biosynthesis process controlled by a number of fatty acid transcription factors. This study investigates the relationships between 130 single-nucleotide polymorphisms (SNPs) in the PPARγ gene and the fatty acid composition of muscle fat in the commercial population of Korean native cattle. We identified 38 SNPs and verified relationships between 3 SNPs (g.1159-71208 A>G, g.42555-29812 G>A, and g.72362 G>T) and the fatty acid composition of commercial Korean native cattle (n = 513). Cattle with the AA genotype of g.1159-71208 A>G and the GG genotype of g.42555-29812 G>A and g.72362 G>T had higher levels of monounsaturated fatty acids and carcass traits (p<0.05). The results revealed that the 3 identified SNPs in the PPARγ gene affected fatty acid composition and carcass traits, suggesting that these 3 SNPs may improve the flavor and quality of beef in commercial Korean native cattle.

Highlights

The fatty acid composition of livestock adipose tissue is recognized as an important carcass trait affecting meat quality
Sci. 29:184-194 fatty acid biosynthesis process is controlled by a number of transcription factors such as peroxisome proliferatoractivated receptor gamma (PPARγ), CCAAT/enhancer binding protein alpha (C/EBPA), and sterol regulatory element binding proteins (SREBPs)
These findings suggest that fatty acid composition may be controlled by genetic factors such as genes related to lipid synthesis and fatty acid metabolism (Narukami et al, 2011)

Summary

Introduction

The fatty acid composition of livestock adipose tissue is recognized as an important carcass trait affecting meat quality. Many studies have reported that genetic factors in transcription factor genes are associated with fatty acid composition and the marbling score in Korean native cattle and Japanese Black cattle (Shin et al, 2007; Hoashi et al, 2007; Lee et al, 2008; Oh et al, 2012). The present study evaluates the relationships between single nucleotide polymorphisms (SNPs) of intron and exon regions in the PPARγ gene and fatty acid composition in Korean native cattle.

Results

Conclusion