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Abstract
BackgroundA study conducted on elderly Korean men showed that a high serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio was associated with a high risk of developing sarcopenia. We aimed to determine such an association in community-dwelling Chinese adults.MethodsFrom May 2016 to August 2017, we conducted a cross-sectional study on Chinese adults at the First Affiliated Hospital of Wenzhou Medical University. Univariate and multivariate logistic regression analyses were applied to evaluate a possible relationship between TG/HDL-C ratio and sarcopenia occurrence.ResultsWe included 2613 adults in this study, with 13.85% presenting with sarcopenia. The odds ratios (ORs) for TG and HDL-C were 0.67 (95% confidence interval [CI]: 0.51–0.87), and 1.97 (95% CI: 1.49–2.61), respectively. Moreover, TG/HDL-C ratio was independently associated with sarcopenia status (OR: 0.63; 95% CI: 0.49–0.81).ConclusionsWe found that TG and HDL-C were, respectively, negatively and positively associated with sarcopenia occurrence rate in community-dwelling Chinese adults. However, a negative association was found between sarcopenia occurrence rate and TG/HDL-C ratio.
Highlights
Sarcopenia, which was defined by the 2014 Asian Working Group for Sarcopenia (AWGS) as the agerelated reduction of muscle mass and function, has drawn public attention worldwide [1,2,3,4,5]
Tae-Ha et al demonstrated that a higher TG/high-density lipoprotein cholesterol (HDL-C) ratio was associated with an increased rate of sarcopenia occurrence in elderly Korean
Cutoffs and clinical features according to grouping By receiver operating characteristic (ROC) curves, TG, diagnostic performances of lipid profile were evaluated (Supplementary Figure)
Summary
Sarcopenia, which was defined by the 2014 Asian Working Group for Sarcopenia (AWGS) as the agerelated reduction of muscle mass and function, has drawn public attention worldwide [1,2,3,4,5]. Many variables, such as age, inflammation, hormonal changes, and cachexia are considered as risk factors of sarcopenia [9,10,11,12,13,14,15]. Jaekyung No et al recently published a metaanalysis and confirmed that serum triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) levels had a positive and negative correlation with sarcopenia, respectively [16]. Tae-Ha et al demonstrated that a higher TG/HDL-C ratio was associated with an increased rate of sarcopenia occurrence in elderly Korean. A study conducted on elderly Korean men showed that a high serum triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio was associated with a high risk of developing sarcopenia. We aimed to determine such an association in community-dwelling Chinese adults
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