Relationship between serum total bile acid and fetal prognosis in patients with intrahepatic cholestasis of pregnancy

Abstract

To explore the relationship between serum total bile acid concentration and fetal prognosis in patients with intrahepatic cholestasis of pregnancy (ICP). A total of 131 ICP patients were divided into mild and severe ICP groups according to serum total bile acid concentration. And another 100 normal subjects during the same period were selected as control group. Their medical records and fetal prognoses were analyzed. The serum total bile acid, liver enzyme and lipid concentration of ICP patients were all significantly higher than those of the controls (P<0.01). The fetal prognoses of ICP patients were significantly different with those of controls (P<0.05). A high serum level of total bile acid of ICP patients may produce serious adverse effects on fetal prognosis. Key words: Bile acids and salts; Infant, newborn