Relationship between serum neutrophil gelatinase-associated lipocalin and kerbs von lungren 6 antigen expressions in early preterm after birth and the development of bronchopulmonary dysplasia

Abstract

Objective To study the relationship between serum neutrophil gelatinase-associated lipocalin (NGAL), kerbs von lungren 6 antigen (KL-6) and bronchopulmonary dysplasia (BPD) in preterm infants. Method From Jan.2015 to Dec.2015, preterm infants admitted to NICU of Guangzhou Women and Childrem′s Medical Center with gestational age less than 32 weeks and birth weight less than 1 500 g were enrolled. The serum levels of procalcitonin (PCT), NGAL and KL-6 protein were detected at 24 h, 7 d and 14 d after birth. At the 28 d after birth, according to the presence of BPD or not, the infants were assigned into BPD group and non-BPD group. The differences of the serum levels of PCT, NGAL and KL-6 between the two groups were compared. Result A total of 55 cases were included in the study (BPD group 20 cases, non-BPD group 35 cases). No significant differences existed in gender, birth weight and gestational age between the two groups (P>0.05). The incidence of respiratory distress syndrome were siginificantly higher in the BPD group (P 0.05). The levels of serum PCT at 7 d and 14 d after birth in BPD group were significantly higher than non-BPD group [7 d: (1.5±1.7) ng/ml vs.(0.4±0.2) ng/ml, 14 d: (0.8±0.7) ng/ml vs.(0.2±0.1) ng/ml] (P 0.05). The levels of serum KL-6 at 7 d and 14 d after birth in BPD group were significantly higher than non-BPD group [7 d: (1.2±0.2) ng/ml vs.(0.8±0.1) ng/ml, 14 d: (1.3±0.2) ng/ml vs.(0.8±0.9) ng/ml] (P<0.001). The level of serum KL-6 at 7 d and 14 d after birth in BPD group were significantly higher than 24 h in BPD group (P<0.05). Conclusion Respiratory distress syndrome and prolonged mechanical ventilation were risk factors of BPD. The rising of serum NGAL and KL-6 early after birth might be involved in the development of BPD, which had predictive value of BPD. Key words: Bronchopulmonary dysplasia; Lipocalins; Neutrophil gelatinase-associated lipocalin; Kerbs von lungren 6 antigen; Infant, premature