Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Polycystic Ovary Syndrome

Shou-Kui Xiang,Ying Tang,Qi Zhuang,Fei Hua,Xiao-Hong Jiang,Feng-Juan Qian

doi:10.1155/2012/173281

Abstract

Objective. To investigate the association between serum lipoprotein ratios and insulin resistance in women with polycystic ovarian syndrome (PCOS). Methods. 105 PCOS patients and 109 controls were randomly enrolled in the study. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), total testosterone (T), fasting glucose (FBG), fasting insulin (FINS), serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) levels were checked, and then TG/HDL-C ratio, TC/HDL-C, ratio and LDL-C/HDL-C ratio were calculated. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate the insulin resistance. Results. All lipoprotein ratios were significantly higher in PCOS patients as compared to healthy controls (P < 0.05). TG/HDL-C ratio, TC/HDL-C ratio, and LDL-C/HDL-C ratio were significantly correlated with HOMA-IR (P < 0.05). The ROC curve demonstrated that TC/HDL-C ratio had higher sensitivity and specificity in diagnosing PCOS with insulin resistance. Conclusion. This study demonstrates that serum lipoprotein ratio significantly correlates with insulin resistance and can be used as the marker of insulin resistance in PCOS patients.

Highlights

Polycystic ovary syndrome (PCOS) is the most common endocrine disease and metabolic disorder in adolescence and reproductive women, which is the first reason for female infertility, with the incidence of 5–10% in reproductive women [1]
body mass index (BMI), waist circumference (WC), SBP, DBP, luteinizing hormone (LH), T, FBG, fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-insulin resistance (IR)), TG, total cholesterol (TC), LDL-C, TG/HDL-C, TC/HDL-C, and LDL-C/HDL-C were significantly higher in PCOS group than in control group
TG/HDL-C Reference line studies have shown that serum lipoprotein ratios (TG/HDLC, TC/HDL-C, and LDL-C/HDL-C) have significant positive correlation with insulin resistance in patients with type 2 diabetes and could be considered as a simple reliable indicator to determine insulin resistance [19]

Summary

Objective

To investigate the association between serum lipoprotein ratios and insulin resistance in women with polycystic ovarian syndrome (PCOS). 105 PCOS patients and 109 controls were randomly enrolled in the study. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate the insulin resistance. All lipoprotein ratios were significantly higher in PCOS patients as compared to healthy controls (P < 0.05). TG/HDL-C ratio, TC/HDL-C ratio, and LDL-C/HDL-C ratio were significantly correlated with HOMA-IR (P < 0.05). The ROC curve demonstrated that TC/HDL-C ratio had higher sensitivity and specificity in diagnosing PCOS with insulin resistance. This study demonstrates that serum lipoprotein ratio significantly correlates with insulin resistance and can be used as the marker of insulin resistance in PCOS patients

Introduction

Materials and Methods

Results

Discussion