Relationship between serum lipid profile and thyroid function after thyroid hormone withdrawal in patients with differentiated thyroid carcinoma

Abstract

Objective To observe the relationship between serum lipid concentration profiles and thyroid function after thyroid hormone withdrawal(THW) in patients with differentiated thyroid carcinoma(DTC). Methods Sixty-five post-operative DTC patients who prepared to receive radioiodine ablation were included in this study. Serum thyroid hormones(TSH, FT4, FT3) and lipid profile[total cholesterol(TC), triglycerides(TG), low-density lipoprotein-cholesterol(LDL-C), and high-density lipoprotein-cholesterol(HDL-C)] levels were measured before and 3 weeks after THW. The relationship between serum lipid profile concentrations and thyroid hormone levels were measured. Results Before surgery, HDL-C level showed a significant positive correlation with TSH level(r=0.273, P=0.041), whereas other lipid profile did not show any significant correlation with thyroid hormones levels. Before THW, no correlation was observed between thyroid hormones and lipid profile. After 3 weeks' THW, the TC level was correlated with FT4 and FT3 levels(r were -0.321 and -0.415, respectively, both P 0.05). Conclusion The serum lipid profile varies with the change of serum thyroid hormones after THW in postoperative DTC patients. (Chin J Endocrinol Metab, 2016, 32: 112-116) Key words: Differentiated thyroid carcinoma; Hypothyroidism; Radioiodine ablation; Lipid profile