Relationship between serum GFPA, IL-6, and MMP9 and hematoma volume and neurological impairment in patients with HICH

Abstract

Objective To investigate the changes and significance of serum glial fibrillary acidic protein (GFPA), interleukin-6 (IL-6), and matrix metalloprotein 9 (MMP-9) in patients with hypertensive intracerebral hemorrhage (HICH). Methods Eighty HICH patients (HICH group) admitted to our hospital from March 2016 to September 2017 and 80 healthy subjects (control group) were selected. The serum levels of GFPA, IL-6, and MMP9 were determined. The relationship between them and hematoma volume and neurological impairment were analyzed. Results The serum levels of GFPA, IL-6, and MMP9 in the HICH group were significantly higher than those in the control group (P<0.05). Serum GFPA, IL-6, and MMP9 levels were different in the HICH group with different hematoma volume (P<0.05). The differences in serum GFPA, IL-6, and MMP9 levels among the HICH patients with different neurological deficit degree were statistically significant (P<0.05). There were significant positive correlation between serum GFPA, IL-6, MMP9 levels and NIHSS score, hematoma volume in patients with HICH (P<0.05). Conclusion The serum levels of GFPA, IL-6, and MMP9 in the HICH patients were significantly higher than those in the healthy people, and were related to the degree of neurological deficit and the amount of hematoma. Key words: Glial fibrillary acidic protein (GFPA); Interleukin-6 (IL-6); Matrix metalloprotein 9 (MMP-9); Hypertensive intracerebral hemorrhage (HICH)