Relationship between serum ferritin level and urinary arsenic concentration

Abstract

relationship between serum ferritin level and urinary arsenic concentrationbackground: studies on the association between serum ferritin levels (s-ft) and urinary arsenic concentrations (u-as) are scarce. the objective of this study was to investigate the relationships between these two parameters using a large-scale nationwide representative sample of the korean. methods: a nationwide cross-sectional study was conducted to examine the relationship between serum ferritin levels and urinary arsenic concentrations in 1,826 men and 1,886 women over 19 years of age (aged 20-80 years), using data from the 2008-2009 korean national health and nutrition examination survey(knhanes). we used analysis of variance (anova) or chi-square test to estimate differences in the demographic and biochemical characteristics of participants. generalized linear models were also used to examine the associations between S-Ft and U-As. results: Mean values of s-ft gradually decreased in accordance with the quartiles of u-as (P-trend<0.001). we found that increased u-as was associated with decreased s-ft (β=-0.01, p<0.05) after adjusting for age, sex, bmi, cigarette smoking, alcohol intake, physical activity, blood pressure, fasting plasma glucose, triglyceride, and high-density lipoprotein cholesterol. in a sex stratified analysis, a significant association was stronger only in male (β=-0.04, p<0.05), not in female(β=0.002, p=0.76). conclusions: we found a negative relationship between s-ft and u-as in a representative population sample of korean adult. our results suggested s-ft as a marker for evaluating early effect of environmental as exposure.keywords: arsenic; ferritin; knhanes;