Abstract
ObjectiveThe prevalence of sarcopenia is high in patients with type 2 diabetes mellitus (T2DM). Oxidative stress and inflammation play important roles in the pathogenesis of sarcopenia in diabetes. Bilirubin has been shown to possess anti-oxidative activity. We aimed to explore the relationship between bilirubin and sarcopenia in patients with T2DM.MethodsA total of 251 patients (124 men and 127 postmenopausal women) with T2DM, aged ≥50 years, participated in a cross-sectional study. The serum concentrations of bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IBIL) were measured. Muscle mass was measured using dual-energy X-ray absorptiometry.ResultsTBIL and IBIL were positively associated with appendicular skeletal muscle mass index (SMI) in men, but not in women. After adjustment for multiple factors in multiple linear regression analysis, TBIL and IBIL were also significantly associated with SMI in men. In multiple logistic regression analysis, participants in the highest quartile of IBIL demonstrated a lower odds ratio for sarcopenia in men.ConclusionsBoth TBIL and IBIL are positively associated with muscle mass in men with T2DM. Furthermore, IBIL may protect against sarcopenia in men with T2DM.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
