Abstract
Sarcopenia has attracted interest due to its impact on various health problems. Chronic inflammation is an important contributor to sarcopenia. Thus, we aimed to investigate the association between serum alkaline phosphatase (ALP), which is a novel inflammatory marker, and muscle mass. This study included 15,579 adults from the 2008–2011 Korea National Health and Nutrition Survey. Low skeletal muscle mass index (LSMI) was defined as body mass index-adjusted appendicular skeletal muscle mass less than 0.789 for men and 0.512 for women. Multiple logistic regression revealed that the highest ALP tertile was significantly associated with LSMI compared with the lowest ALP tertile in both men [Odds ratio (OR): 1.41; 95% confidence interval (CI): 1.04–1.91] and women (OR: 1.45; 95% CI: 1.00–2.10) after adjusting for other confounders. On the receiver operating characteristic curve analysis, the predictive power was significantly higher for ALP levels than for white blood cell count in women (p < 0.001), whereas the difference was not significant in men (p = 0.515). Our findings suggest the potential use of serum ALP as an inflammatory marker and a predictor of sarcopenia.
Highlights
Sarcopenia is a progressive and generalized skeletal muscle disorder, characterized by low muscle strength, low muscle quantity, and low physical performance [1]
Mean blood pressure (MBP), fasting plasma glucose (FPG) and the proportion of people with one or more chronic diseases were significantly increased in both men and women in the sex-specific T3 level compared to
Despite the relatively low areas under the curves (AUC), we found that the predictive power was significantly higher for alkaline phosphatase (ALP) level than for white blood cell (WBC) count in women (AUC of ALP: 0.662, AUC of WBC: 0.605, p < 0.001), whereas the difference was not statistically significant in men (AUC of ALP: 0.562, AUC of WBC: 0.553, p = 0.515)
Summary
Sarcopenia is a progressive and generalized skeletal muscle disorder, characterized by low muscle strength, low muscle quantity, and low physical performance [1]. Sarcopenia was first described as a decrease in muscle mass associated with normal aging in the. Sarcopenia is well known to be associated with frailty, functional decline, and falls in elderly [4]. Emerging evidence has been presented that sarcopenia is associated with a high risk for developing cardiometabolic disorders, such as insulin resistance, type. 2 diabetes, and cardiovascular disease [5,6,7]. These associations could be explained by the multifaceted pathophysiologic causes of sarcopenia, including physical inactivity, inflammation, oxidative stress, hormonal changes, and mitochondrial dysfunction [8]
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