Relationship between serum 25-hydroxy vitamin D level and glycated hemoglobin A1c level in Uygur and Han nationality in a community in Urumqi

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Objective To analyze the relationship between serum 25-hydroxy vitamin D[25(OH)D] level and glycated hemoglobin A1c(HbA1c) level in a Urumqi Uygur and Han community. Method A total of 2 080 cases from a diabetes epidemiological survey conducted in a Urumqi community from May to June 2013 were used. Altogether 1 665 Uygur and Han cases with complete data were included for this study (Uygur/Han: 719/946; male/female: 502/1 163) , with ages ranging from 18 to 82 years old, average age [Uygur/Han: (44±13) / (48±16) years old]. Serum 25 (OH) D level and HbA1c concentration were measured. The correlation between 25(OH)D level and HbA1c level was analyzed. The correlation between ethnics, gender and diabetic status was analyzed. The single factor analysis of variance, t test and Pearson correlation analysis were used for statistical analysis. Results (1) The 25(OH)D level of Uygur was significantly lower than that of Han[(13+7) vs (19±8) μg/L, t=16.543, P 0.05). (2) In Uygur male subjects with adequate 25 (OH) D level, lack of 25(OH)D level or insufficient 25(OH)D level, the HbA1c were different (F=11.763, P<0.001). (3) Correlation analysis found that in Uygur male, 25(OH)D was positively related to HbA1c level (r=0.157, P=0.029) and the difference did not change after controlling for age (r=0.228, P=0.001) . Conclusion In Uygur male subjects, the 25(OH)D level is positively correlated with HbA1c level although the correlation is small. Key words: 25-hydroxy vitamin D; Glycated hemoglobin A1c; Uygur; Han