RELATIONSHIP BETWEEN S-INSULIN AND CHROMIUM, MANGANESE, COBALT, AND ZINC EXCRETION IN THE URINE IN HEALTHY KHYBER PAKHTUNKHWA PERSONS

Abstract

Objective: Clinical research has shown that mineral imbalances, including those involving zinc, cobalt, manganese,and chromium, are crucial for the onset and development of diabetes mellitus. To ascertain the function of these traceelements in pathogenesis and the advancement of type 2 diabetes, this investigation aimed to ascertain if there was alink, if any, between the urine excretion of these minerals and s-insulin levels.Study Design: Cross-sectional study.Place and Duration of study: From January to December 2013, this research was carried out at Khyber MedicalUniversity (KMU), Peshawar, at the Institute of Basic Medical Sciences (IBMS).Materials and Methods: This research comprised 200 healthy people from the seven divisions of Khyber Pakhtunkhwa (Abbottabad, Peshawar, Mardan, Bannu, Dera Ismail Khan, Malakand, and Kohat) with normal fastingblood sugar (FBS), creatinine, cholesterol, HDL, LDL, and TAG values. Anthropometric measures and demographicdata were recorded. Serum creatinine, serum insulin, lipid profile, and fasting blood sugar were measured using a bloodsample. Urine samples were taken early in the morning to measure zinc, cobalt, manganese, and chromium levels.Results: It was discovered that there was a near-to-significant negative connection (r: -0.127, p: 0.073) betweenmanganese and s-insulin and a considerably high negative correlation (r: -0.191, p: 0.007) between chromium ands-insulin. Thus, elevated chromium and manganese excretion in the urine in healthy persons may eventually causeT2DM to proceed if improperly managed.Conclusion: the present study revealed a significant correlation of s-insulin with urinary excretion of chromium only.Keywords: Type II diabetes mellitus, s-insulin, trace elements.