RELATIONSHIP BETWEEN ROUTE OF PROGESTERONE SUPPLEMENTATION, SERUM PROGESTERONE CONCENTRATION, AND LIVE BIRTH FROM VITRIFIED-WARMED BLASTOCYST TRANSFERS: SECONDARY ANALYSES OF A RANDOMIZED CONTROLLED TRIAL (RCT)

Abstract

Recent RCT data indicate that programmed endometrial preparation regimens inclusive of intramuscular progesterone (IMP) are superior to regimens using vaginal progesterone (VP) only, in terms of live birth (LB) from frozen embryo transfer (FET) (1). Studies suggest inferior FET outcomes with lower serum progesterone concentration (P). A recent meta-analysis suggested P <10ng/mL as a negative prognosticator. However, most published analyses relied upon FET with VP only (2). It remains unclear whether P is associated with lower LB when IMP is used.