Relationship between retinol binding protein 4 and diabetic vascular complications

Abstract

The pathogenesis of diabetic vascular disease is complex.It is closely related with high blood glucose,insulin resistance,inflammation,oxidative stress.As an adipocytokine,retinol binding protein 4 (RBP4) participates in atherosclerosis and vascular expansion through insulin resistance,lipid metabolism disorders,oxidative stress and inflammatory reaction,finally leads to diabetic vascular disease.RBP4 is also associated with the pathogenesis of microvascular complications,however,the specific mechanism needs further study.Exercise,lose weight surgery,cholesterol lowering agents--fibrates and the glitazones can reduce RBP4 level,which indicates RBP4 is a new strategy for the treatment of diabetic vascular disease. Key words: Retinol binding protein 4; Diabetic vascular disease; Atherosclerosis; Oxidative stress ; Inflammation