Relationship between resistin and mortality in maintenance hemodialysis patients.

Abstract

Determine the relationship of serum resistin level with outcome in maintenance hemodialysis (HD) patients. This 49-month prospective study enrolled 101 HD patients and examined their clinical and demographic characteristics. 23of the 87 patients in the cohort died. Survivors were younger, had higher body mass index, diastolic blood pressure, and serum levels of albumin, creatinine, potassium, and phosphate, and lower serum levels of resistin. Receiver operating characteristic (ROC) curve analysis indicated the optimal cut-off value of resistin for prediction of mortality was 127.4ng/mL (area under the curve (AUC) = 0.667, p = 0.01). Cox proportional-hazards regression analysis indicated that advanced age (p<0.001) and resistin level above 127.4ng/mL (p = 0.004) were associated with increased mortality risk. Albumin (p = 0.048), creatinine (p= 0.014), potassium (p = 0.023), calcium (p = 0.021), and phosphate (p = 0.001) were associated with decreased mortality risk. Multivariate regression analysis indicated that advanced age (adjusted hazard ratio (aHR) = 1.11, p < 0.0001) and elevated resistin concentration (aHR = 2.442, p = 0.0387) increased the risk for mortality. Advanced age and serum resistin concentration above 127.4ng/mL are independent risk factors for mortality in patients undergoing maintenance HD.