Abstract
目的 研究CT测量的肾脏皮质、实质厚度与肾脏滤过功能的关系,并评价CT预测肾脏滤过功能的价值.方法 选择同时行增强螺旋CT检查和99锝m-二乙三胺五醋酸(99Tcm-DTPA)肾动态显像的89例患者,局部肾脏疾病患者排除在外.根据肾脏滤过功能把178个肾脏分为正常组、肾功能轻度受损组、肾功能重度受损组,比较3组间CT测量的肾脏皮质、实质厚度的差异,分析肾脏皮质、实质厚度与肾脏滤过功能的相关性,并用受试者操作特性曲线(ROC)法评价CT预测肾脏功能的价值.结果 正常组、肾功能轻度受损组、肾功能重度受损组3组间肾脏皮质厚度分别为(5.9±1.1)、(4.6±1.1)、(3.3±1.0)mm,3组间肾脏实质厚度分别为(26.3 ±4.2)、(21.3±4.6)、(16.2±4.6)mm.3组间肾脏皮质、实质厚度差异有统计学意义(F值分别为54.78、43.90,P值均＜0.01).肾脏皮质(r=0.752,P＜0.01)、实质(r=0.738,P＜0.01)厚度与肾脏滤过功能有良好的相关性,CT测量的皮质厚度在预测单侧肾脏功能轻度异常和重度异常时ROC曲线下面积(Az)分别为0.860和0.905;实质分别为0.868和0.884.结论 CT测量肾脏皮质、实质厚度能较准确反映肾脏滤过功能,CT可以作为评价肾脏滤过功能的一种补充方法。
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