Relationship Between Renal Angina Index and D-Dimer Improvement Towards Acute Kidney Injury in Covid-19 Patients in Special Isolation Room of Dr. Soetomo Hospital Surabaya

Abstract

Since the World Health Organization (WHO) declared COVID-19 as pandemic in March 2020, the number of new case findings in Indonesia has continued to increase. As happened in the city of Surabaya. Even in severe cases deterioration is rapid and progressive. One of them is the high D-dimer level in COVID-19 patients, which indicates the presence of vascular thrombosis, resulting in organ failure syndromes such as Acute Kidney Injury (AKI). Such conditions clearly indicate that this virus attacks the kidneys. It is known that the prevalence of AKI is 17%, where 77% of AKI patients experienced severe COVID-19 infection, and 52% died. For this reason, this study was prepared with the aim of knowing the relationship between increased levels of D-Dimer Renal Angine Index and the incidence of Acute Kidney Injury (AKI) in COVID-19 patients in the Special Isolation Room of Dr. Soetomo Hospital Surabaya. This study was a retrospective cohort analytic observational study with a sample size of 30. The Acute Kidney Injury criteria in this study used an increase in serum creatinine ≥ 0.3 mg / dL within 48 hours, or an increase in serum creatinine ≥ 1.5 times. Through research conducted, it is known that the Renal Angina Index can be used to predict the incidence of AKI in this study with p <0.0001 and sensitivity 71%, specificity 21% (r: 0.43; strong CC> 0.3) with a limit of 7. It can be concluded that there is a relationship which is significant between the Renal Angina Index on the incidence of Acute Kidney Injury (AKI). However, there was no significant relationship between increased D-Dimer levels and the incidence of acute kidney injury.