Abstract
Ang (1‐7) causes a natriuresis, which is mediated by intrarenal (IR) Mas receptors but is also dependent upon functional IR AT1 receptors. This study investigated the role played by IR AT2 receptors in mediating the renal excretory actions of Ang (1‐7) normally and when the RAS was stimulated by a low sodium diet. Male Wistar rats (n= 5‐6) were placed on normal (NNa+, 0.2%) or low (LNa+, 0.03%) sodium diets for 2 weeks. Rats were anaesthetized (chloralose/urethane) and prepared for mean arterial pressure (MAP) and left renal function measurement and IR infusion of saline and drugs. Data ±SEM were subjected to a Students t‐test. Basal MAP was 93±4 and 91±2mmHg and basal fractional sodium excretion (FENa) was 1.4±0.3 and 0.7±0.2 % in NNa+ and in LNa+ rats, respectively. IR infusion of Ang1‐7 had no effect on MAP but increased FENa by 227% and 427% in NNa+ and LNa+ rats respectively (both P<0.05). In the presence of PD123319, Ang (1‐7) induced increases in FENa excretion were blunted at 75% and 34% in NNa+ and LNa+ rats respectively (both P<0.05). These data imply that functional IR AT2 receptors may have a permissive effect upon the natriuretic actions of Ang (1‐7) at a tubular level.Grant Funding Source: IRCSET
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
