Abstract
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive method to evaluate the microcirculation of bone marrow in local tissue, which will be a new tool for the diagnosis of osteoporosis. To investigate the relationship between quantitative perfusion parameters (Ktrans, Kep and Ve) and bone mineral density (BMD) in postmenopausal women. The subjects were divided into 3 groups according to T value: normal bone mass group (T value ≥-1.0); bone loss group (-2.5 < T <-1.0); and osteoporosis group (T ≤-2.5). Ktrans, Kep and Ve of the lumbar spine were measured using quantitative DCE-MRI. The relationship between these parameters and age was analyzed. Bone mineral density of the lumbar spine and femoral neck gradually decreased with age. The values of Ktrans, Kep and Ve significantly decreased with age. The values of Ktrans, Kep and Ve of the lumbar vertebrae in the osteoporosis group were lower than those in the bone loss and normal bone mass group. Bone mineral density was positively correlated with the Ktrans and Ve of the lumbar vertebrae. The incidences of bone loss and osteoporosis increased with age. The measurement of BMD was conducive to early diagnosis of osteoporosis. Ktrans, Kep and Ve values of the lumbar vertebra decreased with age, and have a positive correlation with lumbar BMD. The value of DCE-MRI may play a role in the diagnostic algorithm of osteoporosis.
Highlights
Osteoporosis is a systemic skeletal disease characterized by bone loss, microstructural degradation with a resulting increase in bone fragility and, as a consequence, susceptibility to fracture.[1]
The measurement of bone mineral density (BMD) was conducive to early diagnosis of osteoporosis
Kep and volume fraction (Ve) values of the lumbar vertebra decreased with age, and have a positive correlation with lumbar BMD
Summary
Osteoporosis is a systemic skeletal disease characterized by bone loss, microstructural degradation with a resulting increase in bone fragility and, as a consequence, susceptibility to fracture.[1]. Osteoporosis-induced pain, height shortening, humpback, fractures, and other complications seriously reduce the quality of life of patients. Patients are under several economic burdens due to the pain. It is widely known that bone biochemical markers are one of the methods for assessing bone metabolism in humans,[2,3,4,5] but their use has been limited to providing comprehensive information about the overall bone response, which does not reflect changes of the hip or other specific parts. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive method to evaluate the microcirculation of bone marrow in local tissue, which will be a new tool for the diagnosis of osteoporosis
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