Relationship between proinsulin and cardiovascular risk variables in patients with diabetes

Abstract

CO RR EC TE D PR OO F stepwise selection. Results and discussion: Themean age of the study population was 59.1 years (±11.8 years), male sex 60.4 % of the patients. The prevalence of PN in DG and DHG was 53.8% and 60.9% respectively. Total prevalence of PN in this population was 58.2% (95% CI: 42.6%–68.8%). Diabetes duration was 12 years in DG patients and 10 years in DHG patients (p = 0.004). Hepatitis C patients presented a higher value of HbA1c (9.3 vs 8.5, p = 0.001). We observed that the prevalence of PN was higher among men in boths groups. In DH group predictive factors of PN inmultivariate analysis included old age [odds ratio (OR) 3.4 95% 1.5–7.6), p = 0.002], duration of diabetes over 11.5 years [OR = 1.26, CI 95% 1.07–2.009, p = 0.01], alcohol consumption [OR 1.12 95% CI 1.03–3.2, p = 0.04], elevated gammaglutamyl transpeptidase over 85 UI/L [OR 1.5 CI95% 1.2–1.9, p = 0.03], HbA1c over 8.5% [OR 4.2 CI95% 1.6–8.6, p = 0.001]. Conclusions: These findings suggest that peripheral neuropathy is frequent in patients with diabetes and hepatitis C. In this population various factors are associated with neuropathy such as age, alcohol consumption, duration of diabetes and glycemic control.