Relationship between Prenatal Characteristics and Body Condition and Endocrine Profile in Rabbits.

María-Luz García,Raquel Muelas,Rosa Peiró,María-José Argente

doi:10.3390/ani11010095

Abstract

Simple SummaryLitter size is an essential trait in rabbit production, and it depends on ovulation rate and embryonic and foetal survival. The period between 8 and 18 d of gestation is critical for foetal survival, as the placenta controls foetal nutrition during this period. Ovulation rate and foetal survival at 12 d of gestation are affected by body condition and metabolic and hormonal profile. Higher foetal survival is related to a higher number of vessels arriving at the implantation site, and may be due to higher available space for the foetus.This study evaluated the relationship between prenatal characteristics and body condition and endocrine profile. A total of 25 non-lactating multiparous females were used. Body condition, measured as body weight and perirenal fat thickness, non-esterified fatty acids (NEFA), leptin, progesterone and 17β-estradiol were recorded at mating and 12 d of gestation. Ovulation rate, number of foetuses, ovary and foetal weight, length and weight of uterine horn, available space per foetus and maternal and foetal placental morphometry were recorded at 12 d of gestation. Ovulation rate showed a positive linear relationship with number of foetuses, ovary weight and NEFA. A negative linear relationship between ovulation rate and perirenal fat thickness and leptin was obtained. Ovulation rate was maximum when body weight and 17β-estradiol were 4.4 kg and 22.7 pg/mL, respectively. Foetal weight showed a positive relationship with perirenal fat thickness and a negative relationship with leptin. An increase in progesterone and NEFA concentration was related to a positive linear increase in number of foetuses and in uterine horn weight. Space available per foetus was affected both by the number of vessels that reach the implantation site and by position of the foetus in the uterine horn. In conclusion, body condition during mating and early gestation should be maintained within an optimal range to ensure the best prenatal characteristics. While 17β-estradiol, NEFA and leptin affected the ovulation rate, progesterone and NEFA affected foetal development. The number of vessels that reach the implantation site determines early foetal survival.

Highlights

A high ovulation rate and high litter size are characteristics of females in the rabbit industry [1]
This study evaluated the relationship between prenatal characteristics and body condition and endocrine profile
Body condition, measured as body weight and perirenal fat thickness, non-esterified fatty acids (NEFA), leptin, progesterone and 17β-estradiol were recorded at mating and 12 d of gestation

Summary

Introduction

A high ovulation rate and high litter size are characteristics of females in the rabbit industry [1]. Ovulation rate reaches higher values than litter size, approximately 20% to 40% of the ovulated ova do not reach gestational term (see review by [2]). Leptin may act as the critical link between adipose tissue and the reproductive system, indicating whether adequate energy reserves are present for normal reproductive function [17]. Other hormones such as estradiol and progesterone are essential for ovulation and the maintenance of pregnancy [18,19]

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