Abstract
Postural deformities and executive dysfunction (ED) are common symptoms of Parkinson's disease (PD); however, the relationship between postural deformities and ED in patients with PD remains unclear. This study assessed the relationship between postural deformities and ED in patients with PD. Sixty-five patients with sporadic PD were assessed for the severity of postural deformities and executive function. The severity of postural deformities was scored using the United Parkinson's Disease Rating Scale item 28 score: no postural deformity (0), mild postural deformities (1), or severe postural deformities (2–4). Executive function was assessed using the Behavioral Assessment of the Dysexecutive Syndrome (BADS) and an age-controlled standardized BADS score <70 was defined as ED. Age-controlled standardized BADS scores were compared across the three groups using the Kruskal-Wallis test. Relationship between ED and the severity of postural deformities was assessed using the Mann-Whitney U test. Age-controlled standardized BADS score significantly differed among the three groups (P = 0.005). ED was significantly related to the severity of postural deformities (P = 0.0005). The severity of postural deformities was associated with a lower age-controlled standardized BADS score and ED, and these findings suggest that postural deformities were associated with frontal dysfunction in patients with PD.
Highlights
Parkinson’s disease (PD) is a chronic neurodegenerative disease characterized by motor symptoms such as akinesia, rigidity, resting tremor and postural abnormalities, and nonmotor symptoms including dementia, depression, and executive dysfunction (ED) [1]
Previous studies have reported that postural deformities in patients with PD were caused by dystonia, rigidity, impaired proprioception, and kinesthesia; the underlying pathophysiology of postural deformities in patients with PD is unknown [4]
One hundred and forty-eight consecutive patients diagnosed with the sporadic form of PD were registered during the study period, and 65 of these were confirmed as sporadic PD and appropriately assessed using United Parkinson’s Disease Rating Scale (UPDRS) and Behavioural Assessment of the Dysexecutive Syndrome (BADS) and were enrolled in the study
Summary
Parkinson’s disease (PD) is a chronic neurodegenerative disease characterized by motor symptoms such as akinesia, rigidity, resting tremor and postural abnormalities, and nonmotor symptoms including dementia, depression, and executive dysfunction (ED) [1]. These symptoms have a major negative impact on the quality of life of patients with PD [2]. Postural abnormalities in patients with PD include deformities and instability [3]. The relationship between postural deformities and ED in patients with PD has not been determined. The present study assessed the relationship between postural deformities and ED in patients with PD
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