Relationship between postoperative recurrence rate and eosinophil density of nasal polyp: a record based retrospective study

Abstract

<p class="abstract"><strong>Background:</strong> Nasal polyposis is one of the chronic sever airway diseases. It is known as a non-neoplastic inflammatory process of nasal mucosa that eventually leads to the outgrowth of abnormal masses inside the mucosa of nasal cavity and paranasal sinuses. Eosinophils and nasal polyps are believed to affect the surgical outcome of chronic rhinosinusitis (CRS). This study was conducted to determine relationship between postoperative recurrent nasal polyp rate and types of histopathology of nasal polyp.</p><p class="abstract"><strong>Methods:</strong> A retrospective study of 121 patients at Khamis Mushayt General Hospital (Aseer region, Saudi Arabia) from 2012 to 2017. All diagnosed and treated for nasal polyposis with different histopathological types. we collect all the recurrent cases with the same histopathological result. </p><p class="abstract"><strong>Results:</strong> The study included 121 patients with polyps whose ages ranged from 18 to 77 years old. 58% were males and 42% were females. it was noticed that 33.9% of edematous types of polyps with Eosinophilic infiltration were recurrent compared to 25% of other types among patients below the age of 30 years with no statistical significance. At patients above 30 years, the recurrence rate among eosinophilic type was significantly higher than other types (54.5% compared to 13.3%, respectively).</p><p class="abstract"><strong>Conclusions:</strong> Presence of mucosal eosinophilia is a more important factor than nasal polyps for classifying CRS in terms of the surgical outcome. Patients with mucosal eosinophilia had higher polyp recurrence rate than patients without mucosal eosinophilia, whereas patients with nasal polyps did not have higher polyp recurrence rate than patients without nasal polyps.</p>